The Little Salmon River heads in the Meadows Valley in Adams County and flows northward to its confluence with the Salmon River at Riggins.
The Little Salmon River supports spring chinook salmon, steelhead, rainbow trout, cutthroat trout, bull trout, brook trout, mountain whitefish, and nongame species.
The Little Salmon River passes in front of MeadowCreek Resort running parallel to Highway 95.